The Long Covid Research Initiative

A patient-driven movement to accelerate Long Covid Research

0

Million people with Long Covid1

0
Million children with Long Covid1

$386B

Economic cost of Long Covid to the USA to date2

The Long Covid Research Initiative is a movement of patients, researchers and clinicians. We are driving research into the causes of Long Covid to urgently find treatments.

Long Covid is a devastating global health problem – a debilitating disease with tens of millions of sufferers, vast economic costs and no meaningful treatments.

We believe that Long Covid may be a persistent SARS-CoV-2 infection. Whilst there are many theories regarding the pathophysiology – including microclotting, reactivated pathogens, and autoimmunity – persistent infection ties all these theories together. SARS-CoV-2 is one of many viruses which can chronically persist.

We have two focus areas as we investigate the role of persistent infection as a cause of Long Covid:

  • Investigating the underlying pathologies of Long Covid. Particularly identifying virus hiding in the body’s tissues.
  • Establishing adaptive platform trials for rapid testing of repurposed and late stage therapeutics, including antivirals.

RNA for SARS-CoV-2 (pink) and the ACE2 receptor (white), found in salivary gland cells, outlined in green. Credit: NIH.

1 Symptoms lasting longer than 12 weeks. Extrapolated from UK’s ONS data, up to May 6th, 2022. Extrapolated to world population excluding China, adjusted for demographics.

2 Estimate from SolveME whitepaper Long Covid Impact on Adult Americans: Early Indicators Estimating Prevalence and Cost